If you can make a bridge out of Asphalt blocks and equip a variant of the Lightning Boots, you can easily kill the destroyer with piercing projectiles like the Star Cannon or its upgrade Super Star Shooter to kill the destroyer. This is because the destroyer is slower than the character on asphalt blocks.
What is the easiest way to kill the destroyer?
You can summon them with a mechanical worm which is made of six rotten chunks or vertebra. 5 iron or LED bars. And 6 souls a night shoot down through your platform to hit the destroyer.
What is the best weapon to kill the destroyer?
Weapons: Either Clockwork Assault Rifle (Wall of Flesh drop) and party bullets or Minishark with Meteor Bullets. The former has more damage, but the latter is easier to get and can hit twice with each bullet, which is really useful against the destroyer.